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Ruthenium-Catalyzed C–H/N–O Bond Functionalization: Green Isoquinolone Syntheses in Water
Organic Letters · 2011 · Vol. 13(24) · pp. 6548–6551
Lutz Ackermann✉(University of Göttingen)Sabine Fenner(University of Göttingen)
Abstract
Ruthenium-catalyzed isoquinolone syntheses with ample scope were accomplished through carboxylate assistance in environmentally benign water as a reaction medium. The high chemoselectivity of the ruthenium(II) carboxylate complex also set the stage for the direct use of free hydroxamic acids for annulations of alkynes.
Catalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic ReactionsChemoselectivityRutheniumChemistryCarboxylateCatalysisScope (computer science)Combinatorial chemistrySurface modificationOrganic chemistry
MeSH terms
AlkynesBenzamidesCarboxylic AcidsCatalysisColorimetryIsoquinolinesRutheniumWaterMolecular Structure
Funding
- Deutsche Forschungsgemeinschaft
Citations
364
FWCI
19.29
field-weighted impact
References
55
Percentile
100%
vs. same field & year
Citations per year
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References
Phosphine Oxides as Preligands in Ruthenium-Catalyzed Arylations via C−H Bond Functionalization Using Aryl Chlorides
Organic Letters · 2005 · 369 citations
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Angewandte Chemie International Edition · 2009 · 2,728 citations
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
Chemical Reviews · 2009 · 3,657 citations
Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates
Tetrahedron · 2009 · 556 citations
Pd-catalyzed oxidative coupling with organometallic reagents via C–H activation
Chemical Communications · 2010 · 775 citations
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Chemical Reviews · 2010 · 6,049 citations
Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation
Chemical Society Reviews · 2011 · 2,337 citations
Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage
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