article Open AccessTop 1% cited
deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution
Genome biology · 2016 · Vol. 17(1) · pp. 31–31
Rachel Rosenthal(The Honourable Society of Lincoln's Inn)Nicholas McGranahan(CRUK Lung Cancer Centre of Excellence)Javier Herrero(CRUK Lung Cancer Centre of Excellence)Barry S. Taylor✉(Molecular Oncology (United States))Charles Swanton(The Francis Crick Institute)
Abstract
deconstructSigs confers the ability to define mutational processes driven by environmental exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implications for precision cancer medicine.
Cancer Genomics and DiagnosticsGenetic factors in colorectal cancerDNA Repair MechanismsBiologyGeneticsHuman geneticsEvolutionary biologyComputational biologyDNADNA repairGene
MeSH terms
AdenocarcinomaCarcinoma, Squamous CellCytidine DeaminaseDNA Mutational AnalysisDNA RepairEsophageal NeoplasmsHumansMutationGenome, HumanDNA Repair-Deficiency Disorders
Funding
- Novo Nordisk UK Research Foundation
- Rosetrees Trust
- Medical Research Council
- European Research Council
Citations
1,314
FWCI
40.98
field-weighted impact
References
9
Percentile
100%
vs. same field & year
Citations per year
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References
Deciphering Signatures of Mutational Processes Operative in Human Cancer
Cell Reports · 2013 · 1,371 citations
Microsatellite Instability in Colorectal Cancer
Gastroenterology · 2010 · 2,422 citations
Signatures of mutational processes in human cancer
Nature · 2013 · 10,018 citations
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
Science Translational Medicine · 2015 · 707 citations
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