review Open AccessTop 1% cited

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Metabolism · 2016 · Vol. 65(8) · pp. 1038–1048

Elena Buzzetti(The Royal Free Hospital)Massimo Pinzani(The Royal Free Hospital)Emmanuel Tsochatzis✉(The Royal Free Hospital)

View via DOI Publisher page

Liver Disease Diagnosis and Treatment Diet, Metabolism, and Disease Alcohol Consumption and Health EffectsFatty liverSteatohepatitisPathogenesisInsulin resistanceContext (archaeology)Nonalcoholic fatty liver diseaseDiseaseSteatosisFibrosisBioinformatics

MeSH terms

Gastrointestinal MicrobiomeHumansInsulin ResistanceGenetic Predisposition to DiseaseMetabolic SyndromeEpigenesis, GeneticNon-alcoholic Fatty Liver Disease

Citations

2,976

FWCI

116.56

field-weighted impact

References

151

Percentile

100%

vs. same field & year

Citations per year

Cited by

Exploring the hepatoprotective roles of kasni (Cichorium intybus) and behidana (Cydonia oblonga) in non-alcoholic fatty liver disease: A traditional approach to a modern epidemic: A comprehensive review

International Journal of Unani and Integrative Medicine · 2025 · 0 citations

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Cell Death and Disease · 2020 · 480 citations

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

Cell Reports · 2018 · 669 citations

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

Metabolism · 2018 · 1,193 citations

MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease

Gastroenterology · 2020 · 3,178 citations

References

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Nature Medicine · 2005 · 2,216 citations

Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

Physiological Reviews · 2001 · 3,020 citations

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

Gastroenterology · 2015 · 2,900 citations

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Nature Genetics · 2003 · 6,253 citations

Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis

Hepatology · 2010 · 2,405 citations

Critical nodes in signalling pathways: insights into insulin action

Nature Reviews Molecular Cell Biology · 2006 · 2,697 citations

Inflammation and metabolic disorders

Nature · 2006 · 8,779 citations

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

Nature Reviews Molecular Cell Biology · 2008 · 2,250 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.