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Brief but Efficient: Acute HIV Infection and the Sexual Transmission of HIV

The Journal of Infectious Diseases · 2004 · Vol. 189(10) · pp. 1785–1792
Christopher D. PilcherHsiao Chuan TienJoseph J. EronPietro VernazzaSzu‐Yun LeuPaul W. StewartLi‐Ean GohMyron S. Cohen

Abstract

Empirical biological data strongly support the hypothesis that sexual transmission by acutely infected individuals has a disproportionate effect on the spread of HIV-1 infection. Acute hyperinfectiousness may, in part, explain the current pandemic in heterosexual individuals.

HIV/AIDS Research and InterventionsHIV Research and TreatmentHIV, Drug Use, Sexual RiskSemenTransmission (telecommunications)ImmunologySexual transmissionViral diseaseVirologyMedicineSexually transmitted diseaseSex organHuman immunodeficiency virus (HIV)

MeSH terms

CoitusFemaleHumansMaleModels, BiologicalRetrospective StudiesRNA, ViralSemenViremiaModels, StatisticalCohort StudiesHIV-1HIV InfectionsDisease Transmission, InfectiousReverse Transcriptase Polymerase Chain Reaction

Funding

  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • National Institutes of Health
  • Center for AIDS Research, University of Washington
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • Center for AIDS Research, University of North Carolina at Chapel Hill
Citations
666
FWCI
20.47
field-weighted impact
References
41
Percentile
100%
vs. same field & year
Citations per year
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Brief but Efficient: Acute HIV Infection and the Sexual Transmission of HIV
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