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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

Cardiovascular Research · 2013 · Vol. 99(1) · pp. 164–174

Øystein Sandanger✉Trine Ranheim(Oslo University Hospital)Leif Erik Vinge(University of Oslo)Marte Bliksøen(University of Oslo)Katrine Alfsnes(Oslo University Hospital)Alexandra Vanessa Finsen(Oslo University Hospital)Christen P. Dahl(Oslo University Hospital)Erik T. Askevold(University of Oslo)Geir Florholmen(University of Oslo)Geir Christensen(University of Oslo)Katherine A. FitzgeraldEgil LienGuro Valen(University of Oslo)Terje Espevik(Norwegian University of Science and Technology)Pål Aukrust(University of Oslo)Arne Yndestad(Oslo University Hospital)

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Abstract

This study shows that the NLRP3 inflammasome is up-regulated in myocardial fibroblasts post-MI, and may be a significant contributor to infarct size development during ischaemia-reperfusion.

Inflammasome and immune disorders Kawasaki Disease and Coronary Complications Pulmonary Hypertension Research and TreatmentsInflammasomeMedicinePyrin domainIschemiaCardiac function curveReperfusion injuryMyocardial infarctionCaspase 1Internal medicineLigation

MeSH terms

NLR Family, Pyrin Domain-Containing 3 ProteinAdenosine TriphosphateAnimalsCarrier ProteinsCells, CulturedCytoskeletal ProteinsDisease Models, AnimalFibroblastsHeart VentriclesLipopolysaccharidesMaleMice, Inbred C57BLMyocardial ContractionMyocardial InfarctionPotassium