article Open AccessTop 10% cited
Intraperitoneal Chemotherapy of Peritoneal Carcinomatosis Using Pressurized Aerosol as an Alternative to Liquid Solution: First Evidence for Efficacy
Annals of Surgical Oncology · 2013 · Vol. 21(2) · pp. 553–559
Wiebke Solaß✉(Ruhr University Bochum)Reinhold Kerb(University Children's Hospital Tübingen)Thomas E. Mürdter(Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology)Urs Giger-Pabst(Ruhr University Bochum)Dirk Strumberg(Ruhr University Bochum)Clemens Tempfer(Ruhr University Bochum)Jürgen Zieren(Universitätsklinik Marien Hospital Herne)Matthias Schwab(University Children's Hospital Tübingen)Marc A. Reymond(Ruhr University Bochum)
Abstract
PIPAC shows superior pharmacological properties with high local concentration and low systemic exposure. PIPAC can induce regression of PC in chemoresistant tumors, using 10% of a usual systemic dose.
Intraperitoneal and Appendiceal MalignanciesAppendicitis Diagnosis and ManagementOvarian cancer diagnosis and treatmentPeritoneal carcinomatosisMedicineSurgical oncologyChemotherapyDoxorubicinCisplatinAbdomenPeritoneumIntraperitoneal chemotherapySurgery
MeSH terms
AdultAerosolsAgedAntineoplastic Combined Chemotherapy ProtocolsAppendiceal NeoplasmsFemaleHumansInjections, IntraperitonealMaleMiddle AgedNeoplasm StagingOvarian NeoplasmsPeritoneal NeoplasmsPressureStomach Neoplasms
Funding
- Robert Bosch Stiftung
- Bundesministerium für Bildung und Forschung
Citations
367
FWCI
10.17
field-weighted impact
References
18
Percentile
99%
vs. same field & year
Citations per year
References
High interstitial fluid pressure — an obstacle in cancer therapy
Nature reviews. Cancer · 2004 · 2,134 citations
Drug penetration in solid tumours
Nature reviews. Cancer · 2006 · 2,726 citations
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