article Open AccessTop 1% cited
Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
Journal of neurosurgery · 2015 · Vol. 122(4) · pp. 856–867
Yanlu Zhang✉Michael Chopp(Henry Ford Hospital)Yuling MengMark Katakowski(Henry Ford Hospital)Hongqi Xin(Henry Ford Hospital)Asim MahmoodYe Xiong
Abstract
The authors demonstrate for the first time that MSC-generated exosomes effectively improve functional recovery, at least in part, by promoting endogenous angiogenesis and neurogenesis and by reducing inflammation in rats after TBI. Thus, MSC-generated exosomes may provide a novel cell-free therapy for TBI and possibly for other neurological diseases.
Extracellular vesicles in diseaseTraumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesMedicineMorris water navigation taskNeuroinflammationTraumatic brain injuryNeurogenesisDentate gyrusMesenchymal stem cellLesionPathologyHippocampus
MeSH terms
Doublecortin ProteinAnimalsBlood VesselsBrain InjuriesCell CountCognitionInjections, IntravenousMaleNeuronal PlasticitySensationRats, WistarMaze LearningRecovery of FunctionPluripotent Stem CellsMesenchymal Stem Cell Transplantation
Funding
- National Institutes of Health
Citations
736
FWCI
25.16
field-weighted impact
References
115
Percentile
100%
vs. same field & year
Citations per year
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Neurosurgery · 2003 · 476 citations
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