articleTop 1% cited
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Nature Biotechnology · 2011 · Vol. 29(4) · pp. 341–345
Lydia Alvarez‐Erviti✉(University of Oxford)Yiqi Seow(University of Oxford)HaiFang Yin(University of Oxford)Corinne Betts(University of Oxford)Samira Lakhal(University of Oxford)Matthew J. A. Wood(University of Oxford)
RNA Interference and Gene DeliveryExtracellular vesicles in diseaseAdvanced biosensing and bioanalysis techniquesMicrovesiclesGene knockdownExosomeSmall interfering RNAElectroporationCell biologyImmunogenicityRNARNA interferenceGene silencing
MeSH terms
Alzheimer DiseaseAnimalsBrainCell LineDendritic CellsGenetic VectorsMaleMembrane ProteinsMice, Inbred C57BLNeuronsPeptidesProteinsRabies virusRNA, MessengerAspartic Acid Endopeptidases
Citations
4,710
FWCI
64.28
field-weighted impact
References
21
Percentile
100%
vs. same field & year
Citations per year
Cited by
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes
Cells · 2019 · 1,089 citations
Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice
Movement Disorders · 2014 · 496 citations
Advances in therapeutic applications of extracellular vesicles
Science Translational Medicine · 2019 · 983 citations
Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
Advanced Science · 2018 · 575 citations
Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis
Cells · 2019 · 3,092 citations
Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles
Cells · 2020 · 500 citations
Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages
American Journal of Physiology-Cell Physiology · 2014 · 478 citations
Exosomes as drug delivery vehicles for Parkinson's disease therapy
Journal of Controlled Release · 2015 · 1,909 citations
References
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Nature Cell Biology · 2008 · 4,954 citations
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Nature Cell Biology · 2007 · 12,686 citations
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Journal of Immunological Methods · 1983 · 55,054 citations
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
The Journal of Experimental Medicine · 1992 · 3,752 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.