article Open AccessTop 10% cited
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
Gut · 2004 · Vol. 54(1) · pp. 142–151
Liang‐Guo Xu(Icahn School of Medicine at Mount Sinai)A Y Hui(Icahn School of Medicine at Mount Sinai)E Albanis(Icahn School of Medicine at Mount Sinai)M J Arthur(Icahn School of Medicine at Mount Sinai)S M O’Byrne(Columbia University)W S Blaner(Columbia University)P Mukherjee(Cornell University)S L Friedman✉(Icahn School of Medicine at Mount Sinai)F J Eng(Icahn School of Medicine at Mount Sinai)
Abstract
LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease. Both lines retain key features of HSCs. Two unique advantages of LX-2 are their viability in serum free media and high transfectability.
Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and ImmunityHepatic stellate cellBiologyHepatic fibrosisCell cultureMolecular biologyVimentinReceptorFibrosisCell biologyPathology
MeSH terms
Cell LineCulture MediaHumansIntermediate Filament ProteinsLiverLiver CirrhosisTransfectionVitamin AGene ExpressionCulture Media, Serum-FreeAdipocytesMatrix MetalloproteinasesCollagen Type I
Funding
- U.S. Department of Defense
- American Liver Foundation
- National Institutes of Health
Citations
1,006
FWCI
8.78
field-weighted impact
References
53
Percentile
98%
vs. same field & year
Citations per year
Cited by
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Physiological Reviews · 2008 · 2,757 citations
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
Gut · 2004 · 1,006 citations
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References
Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury
Journal of Biological Chemistry · 2000 · 2,089 citations
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
Gut · 2004 · 1,006 citations
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