review Open AccessTop 1% cited
Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury
Journal of Biological Chemistry · 2000 · Vol. 275(4) · pp. 2247–2250
Scott L. Friedman✉(Icahn School of Medicine at Mount Sinai)
Abstract
Encapsulation of injury with fibrosis is a highly evolved response of adult tissues. In liver, the components of the process have been greatly clarified, leading to a coherent view of how wound healing occurs in response to injury. Hepatic fibrogenesis provides an important biological and clinical context for emerging concepts in molecular biochemistry that is relevant to many other tissues.
Liver physiology and pathologyLiver Disease Diagnosis and TreatmentOrgan Transplantation Techniques and OutcomesFibrosisLiver injuryWound healingExtracellular matrixPathologyCholangiocyteBiologyCirrhosisHepatic stellate cellCancer research
MeSH terms
ChemotaxisExtracellular MatrixLiver CirrhosisPhenotypeCytokines
Funding
- National Institutes of Health
Citations
2,089
FWCI
52.28
field-weighted impact
References
54
Percentile
100%
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Citations per year
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