article Open AccessTop 1% cited
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
Cancer Cell · 2006 · Vol. 9(6) · pp. 425–434
Valeria R. Fantin(Howard Hughes Medical Institute)Julie St‐Pierre(Harvard University)Philip Leder✉(Howard Hughes Medical Institute)
Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyATP Synthase and ATPases ResearchGlycolysisBiologyLactate dehydrogenaseMitochondrionCell biologyCancer cellWarburg effectLactate dehydrogenase ACellular respirationCell physiology
MeSH terms
Lactate Dehydrogenase 5Adenosine TriphosphateAnimalsCell Transformation, NeoplasticFemaleGlucoseGlycolysisHumansIndolesIsoenzymesL-Lactate DehydrogenaseMammary Glands, AnimalMammary Neoplasms, ExperimentalMembrane PotentialsMitochondria
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Why do cancers have high aerobic glycolysis?
Nature reviews. Cancer · 2004 · 4,733 citations
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Trends in Biochemical Sciences · 1999 · 1,095 citations
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
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