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Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Clinical Chemistry · 2009 · Vol. 55(11) · pp. 1977–1983
Omar Laterza(Merck & Co., Inc., Rahway, NJ, USA (United States))Lee P. LimPhilip W. Garrett-Engele(Merck & Co., Inc., Rahway, NJ, USA (United States))Kateřina VlasákováNagaraja MuniappaWesley Tanaka(Merck & Co., Inc., Rahway, NJ, USA (United States))Jason M. Johnson(Merck & Co., Inc., Rahway, NJ, USA (United States))Joseph F. SinaThomas L. Fare(United States Military Academy)Frank D. SistareWarren E. Glaab✉
Abstract
These results demonstrate that tissue-specific miRNAs may serve as diagnostically sensitive plasma biomarkers of tissue injury.
MicroRNA in disease regulationExtracellular vesicles in diseaseMesenchymal stem cell researchmicroRNAToxicityLiver injuryBiologyMuscle tissueLiver tissueEndogenyBrain tissueBlood plasmaPathology
MeSH terms
AnimalsFemaleHeart InjuriesKidneyLiverMaleMyocardiumWounds and InjuriesBiomarkersRats, Sprague-DawleyMuscle, SkeletalStrokeMicroRNAsRats
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Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
Genome biology · 2004 · 1,594 citations
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