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Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study

European Journal of Endocrinology · 2011 · Vol. 165(5) · pp. 687–701
Giovanni CoronaGiulia RastrelliMatteo MonamiAndré GuayJ BuvatAlessandra SforzaGianni FortiEdoardo MannucciMario Maggi

Abstract

Lower testosterone and higher E(2) levels correlate with increased risk of CVD and CV mortality. TRT in hypogonadism moderates metabolic components associated with CV risk. Whether low testosterone is just an association with CV risk, or an actual cause-effect relationship, awaits further studies.

Hormonal and reproductive studiesHypothalamic control of reproductive hormonesPharmacological Effects and AssaysTestosterone (patch)MedicineInternal medicineHazard ratioBody mass indexRisk factorEndocrinologyProportional hazards modelLogistic regressionConfidence interval

MeSH terms

AnimalsCardiovascular DiseasesEstradiolHumansHypogonadismMaleRisk FactorsTestosteroneRandomized Controlled Trials as Topic
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433
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26.38
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140
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References
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Testosterone Therapy in Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline
The Journal of Clinical Endocrinology & Metabolism · 2010 · 1,949 citations
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