article Open AccessTop 1% cited
p53 Has a Direct Apoptogenic Role at the Mitochondria
Molecular Cell · 2003 · Vol. 11(3) · pp. 577–590
Motohiro Mihara(Stony Brook University)Susan Erster(Stony Brook University)Alexander Zaika(Stony Brook University)Oleksi Petrenko(Stony Brook University)Thomas Chittenden(ImmunoGen (United States))Petr Pančoška(University of Illinois Chicago)Ute M. Moll✉(Stony Brook University)
Cancer-related Molecular PathwaysCell death mechanisms and regulationCancer Research and TreatmentsBiologyMitochondrionCell biologyComputational biology
MeSH terms
AnimalsCytochrome c GroupDNAHeLa CellsHumansMice, Inbred C57BLMicrosomes, LiverMitochondriaModels, MolecularMutationPlasmidsProtein BindingStructure-Activity RelationshipTranscription, GeneticTransfection
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References
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Molecular Cell · 2001 · 2,283 citations
Mechanisms of p53-dependent apoptosis
Biochemical Society Transactions · 2001 · 533 citations
PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
Molecular Cell · 2001 · 1,277 citations
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
The Journal of Cell Biology · 1997 · 1,800 citations
Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane
Molecular and Cellular Biology · 2000 · 1,203 citations
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Molecular Cell · 2001 · 1,688 citations
A matter of life and death
Cancer Cell · 2002 · 1,236 citations
Mechanisms of p53-dependent apoptosis
Biochemical Society Transactions · 2001 · 501 citations
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