reviewTop 1% cited

Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

Neurobiology of Aging · 2006 · Vol. 27(4) · pp. 570–575

Charles Glabe✉(University of California, Irvine)

Alzheimer's disease research and treatments Prion Diseases and Protein Misfolding Parkinson's Disease Mechanisms and TreatmentsPathogenesisAmyloid (mycology)DiseaseProtein foldingMechanism (biology)Amyloid diseaseBiochemistry of Alzheimer's diseaseBiologyProtein aggregationFibril

MeSH terms

AmyloidAnimalsHumansModels, BiologicalProtein ConformationStructure-Activity RelationshipAmyloid beta-PeptidesProtein FoldingNeurodegenerative DiseasesMacromolecular Substances

Funding

Foundation for the National Institutes of Health
Larry L. Hillblom Foundation

Citations

564

FWCI

16.37

field-weighted impact

References

Percentile

100%

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Citations per year

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References

X-RAY DIFFRACTION STUDIES ON AMYLOID FILAMENTS

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

American Journal of Physiology-Cell Physiology · 2004 · 2,551 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

Science · 2002 · 13,715 citations

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Nature Genetics · 2004 · 2,306 citations

Thioflavine T interaction with synthetic Alzheimer's disease <i>β</i>‐amyloid peptides: Detection of amyloid aggregation in solution

Protein Science · 1993 · 2,237 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Journal of Neuroscience · 1992 · 1,614 citations

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