article Open AccessTop 1% cited
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Nature Genetics · 2004 · Vol. 36(6) · pp. 585–595
Brinda Ravikumar✉(Addenbrooke's Hospital)Corinne Vacher(Addenbrooke's Hospital)Zdenek Berger(Addenbrooke's Hospital)J. Eric Davies(Addenbrooke's Hospital)Shouqing Luo(Addenbrooke's Hospital)Lourdes Garcia Oroz(Addenbrooke's Hospital)Francesco Scaravilli(University College London)Douglas F. Easton(Cancer Research UK)Rainer Duden(Addenbrooke's Hospital)Cahir J. O’Kane(University of Cambridge)David C. Rubinsztein(Addenbrooke's Hospital)
Genetic Neurodegenerative DiseasesMitochondrial Function and PathologyMuscle Physiology and DisordersAutophagyHuntingtinHuntington's diseaseNeurodegenerationPI3K/AKT/mTOR pathwayBiologyHuntingtin ProteinPolyglutamine tractCell biologyMechanistic target of rapamycin
MeSH terms
Huntingtin ProteinAnimalsAutophagyDisease Models, AnimalDrosophila melanogasterFemaleHumansHuntington DiseaseMaleMice, TransgenicMutationNerve Tissue ProteinsNuclear ProteinsPeptidesProtein Kinases
Funding
- Wellcome Trust
- Commonwealth Scholarship Commission
- Cambridge Overseas Trust
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
Citations
2,306
FWCI
26.94
field-weighted impact
References
49
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100%
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References
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
The EMBO Journal · 2000 · 6,511 citations
Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation
Molecular Biology of the Cell · 2001 · 629 citations
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
Human Molecular Genetics · 2002 · 1,084 citations
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin [published erratum appears in Hum Mol Genet 1999 May;8(5):943]
Human Molecular Genetics · 1999 · 747 citations
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