article Open AccessTop 1% cited
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Gut · 2005 · Vol. 55(2) · pp. 205–211
Chaysavanh Manichanh(Virologie et Immunologie Moléculaires)L Rigottier-Gois(Virologie et Immunologie Moléculaires)E Bonnaud(Virologie et Immunologie Moléculaires)K Gloux(Virologie et Immunologie Moléculaires)E Pelletier(Genoscope)L Frangeul(Institut Pasteur)R NalinC JarrinP Chardon(Commissariat à l'Énergie Atomique et aux Énergies Alternatives)P Marteau(Hôpital Européen Georges-Pompidou)J Roca(Institut de Biologia Molecular de Barcelona)J Dore✉(Fondation HEC)
Abstract
The metagenomic approach allowed us to detect a reduced complexity of the bacterial phylum Firmicutes as a signature of the faecal microbiota in patients with CD. It also indicated the presence of new bacterial species.
Gut microbiota and healthInflammatory Bowel DiseaseMycobacterium research and diagnosisFirmicutesMetagenomicsBiologyBacteroidetesPhylum16S ribosomal RNAFosmidMicrobiologyMicrobiomeGenetics
MeSH terms
AdolescentAdultBacteriaCrohn DiseaseDNA, BacterialFecesFemaleHumansMalePhylogenyRNA, BacterialRNA, Ribosomal, 16SBacterial Typing TechniquesGene LibraryIn Situ Hybridization, Fluorescence
Funding
- Institut National de la Recherche Agronomique
Citations
2,250
FWCI
16.77
field-weighted impact
References
41
Percentile
100%
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Citations per year
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