article Open AccessTop 10% cited
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Gut · 2000 · Vol. 47(3) · pp. 397–403
Jean‐Pierre Segain✉(Centre d'Investigation Clinique de Nantes)D Raingeard de la Blétière(Inserm)A Bourreille(Inserm)V Leray(Inserm)N Gervois(Inserm)C Rosales(Inserm)L Ferrier(Inserm)C Bonnet(Centre d'Investigation Clinique de Nantes)H M Blottière(Inserm)J-P Galmiche(Inserm)
Abstract
Butyrate decreases proinflammatory cytokine expression via inhibition of NFkappaB activation and IkappaBalpha degradation. These anti-inflammatory properties provide a rationale for assessing butyrate in the treatment of CD.
Inflammatory Bowel DiseaseNF-κB Signaling PathwaysImmune Response and InflammationProinflammatory cytokineButyrateTumor necrosis factor alphaCytokineLamina propriaLipopolysaccharideInflammationImmunologyPeripheral blood mononuclear cellBiology
MeSH terms
AdolescentAdultAgedAnimalsButyratesCells, CulturedCrohn DiseaseDose-Response Relationship, DrugDrug EvaluationFemaleGastrointestinal AgentsHumansInterleukin-1Leukocytes, MononuclearMale
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References
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Annual Review of Immunology · 1996 · 5,952 citations
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