article Open AccessTop 1% cited
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
Journal of Clinical Oncology · 2005 · Vol. 23(31) · pp. 7794–7803
William J. Gradishar✉(Baylor University Medical Center)Sergei Tjulandin(Baylor University Medical Center)Neville Davidson(Baylor University Medical Center)Heather Shaw(Baylor University Medical Center)Neil Desai(Baylor University Medical Center)Paul Bhar(Baylor University Medical Center)Michael Hawkins(Baylor University Medical Center)Joyce O’Shaughnessy(Baylor University Medical Center)
Abstract
ABI-007 demonstrated greater efficacy and a favorable safety profile compared with standard paclitaxel in this patient population. The improved therapeutic index and elimination of corticosteroid premedication required for solvent-based taxanes make the novel albumin-bound paclitaxel ABI-007 an important advance in the treatment of MBC.
Cancer Treatment and PharmacologyHER2/EGFR in Cancer ResearchMultiple Myeloma Research and TreatmentsMedicinePaclitaxelPremedicationNeutropeniaBreast cancerTaxaneMetastatic breast cancerInternal medicineGastroenterologyFebrile neutropenia
MeSH terms
Albumin-Bound PaclitaxelAdultAgedAlbuminsAntineoplastic Agents, PhytogenicBreast NeoplasmsCastor OilFemaleHumansInfusions, IntravenousMiddle AgedSurvival RateTreatment OutcomePaclitaxelDisease-Free Survival
Funding
- Bristol-Myers Squibb
- American Society of Clinical Oncology
Citations
2,110
FWCI
23.51
field-weighted impact
References
35
Percentile
100%
vs. same field & year
Citations per year
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References
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
JNCI Journal of the National Cancer Institute · 2000 · 15,689 citations
Cremophor EL
European Journal of Cancer · 2001 · 1,626 citations
Nonparametric Estimation from Incomplete Observations
Journal of the American Statistical Association · 1958 · 38,793 citations
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