article Open AccessTop 1% cited
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
Nature Genetics · 2009 · Vol. 41(2) · pp. 178–186
Rafael A. Irizarry✉(Johns Hopkins University)Christine Ladd‐Acosta(Johns Hopkins University)Bo Wen(Johns Hopkins Medicine)Zhijin Wu(Brown University)Carolina Montaño(Johns Hopkins University)Patrick Onyango(Johns Hopkins University)Hengmi Cui(Johns Hopkins Medicine)Kevin Gabo(Johns Hopkins Medicine)Michael Rongione(Johns Hopkins Medicine)Maree J. Webster(Uniformed Services University of the Health Sciences)Hong Ji(Johns Hopkins Medicine)James B. Potash(Johns Hopkins University)Sarven Sabunciyan(Johns Hopkins Medicine)Andrew P. Feinberg(Johns Hopkins University)
Epigenetics and DNA MethylationCancer-related gene regulationGenomics and Chromatin DynamicsBiologyDNA methylationCpG siteEpigeneticsMethylationCancer epigeneticsCancerEpigenetics of physical exerciseGeneticsCancer research
MeSH terms
CarcinomaChromosome MappingColonic NeoplasmsHumansOrgan SpecificityDNA Modification MethylasesGenome, HumanGene Expression Regulation, NeoplasticConserved SequenceCpG IslandsDNA MethylationOligonucleotide Array Sequence AnalysisGene SilencingGene Expression ProfilingHCT116 Cells
Funding
- Stanley Medical Research Institute
- National Institutes of Health
Citations
2,237
FWCI
74.35
field-weighted impact
References
39
Percentile
100%
vs. same field & year
Citations per year
Cited by
A decade of exploring the cancer epigenome — biological and translational implications
Nature reviews. Cancer · 2011 · 2,835 citations
CpG islands and the regulation of transcription
Genes & Development · 2011 · 3,188 citations
Epigenetic modifications and human disease
Nature Biotechnology · 2010 · 2,844 citations
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Nature Reviews Genetics · 2012 · 6,155 citations
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
BMC Cancer · 2009 · 314 citations
Navigating the DNA methylation landscape of cancer
Trends in Genetics · 2021 · 986 citations
DNA Methylation and Its Basic Function
Neuropsychopharmacology · 2012 · 4,803 citations
DNA methylation aging clocks: challenges and recommendations
Genome biology · 2019 · 1,065 citations
References
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
Nature Genetics · 2007 · 2,247 citations
DNA methylation in cancer: too much, but also too little
Oncogene · 2002 · 1,545 citations
The epigenetic progenitor origin of human cancer
Nature Reviews Genetics · 2005 · 1,846 citations
The history of cancer epigenetics
Nature reviews. Cancer · 2004 · 2,348 citations
CpG Islands in vertebrate genomes
Journal of Molecular Biology · 1987 · 3,412 citations
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1995 · 106,483 citations
A comparison of normalization methods for high densityoligonucleotide array data based on variance and bias
Bioinformatics · 2003 · 8,399 citations
The positive false discovery rate: a Bayesian interpretation and the q-value
The Annals of Statistics · 2003 · 2,280 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.