article Open AccessTop 10% cited

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

BMC Cancer · 2009 · Vol. 9(1) · pp. 401–401

Aaron L. Sarver✉(University of Minnesota)Amy J. French(Mayo Clinic)Pedro M. Borralho(University of Lisbon)Venugopal Thayanithy(University of Minnesota)Ann L. Oberg(Mayo Clinic in Florida)Kevin A.T. Silverstein(University of Minnesota)Bruce W. Morlan(Mayo Clinic in Florida)Shaun M. Riska(Mayo Clinic in Florida)Lisa A. Boardman(Mayo Clinic)Julie M. Cunningham(Mayo Clinic)Subbaya Subramanian(University of Minnesota)Liang Wang(Mayo Clinic)Tom Smyrk(Mayo Clinic)Cecília MP Rodrigues(University of Lisbon)Stephen N. Thibodeau(Mayo Clinic)Clifford J. Steer(University of Minnesota)

View via DOI Full-text PDF

Abstract

Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states.

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms researchmicroRNAColorectal cancerEpigeneticsBiologyGene expressionCancer researchRegulation of gene expressionGene expression profilingSurgical oncologyGene

MeSH terms

Cell DifferentiationCell Transformation, NeoplasticColonic NeoplasmsHumansNeoplasm StagingGene ExpressionDNA MethylationReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingMicroRNAsMicrosatellite InstabilityDNA Mismatch Repair