article Open AccessTop 1% cited
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Diabetes · 2009 · Vol. 58(7) · pp. 1526–1531
Masayuki Saito✉(Tenshi College)Yuko Okamatsu‐Ogura(Hokkaido University)Mami Matsushita(Tenshi College)Kumiko Watanabe(Tenshi College)Takeshi Yoneshiro(Tenshi College)Junko Nio‐Kobayashi(Hokkaido University)Toshihiko Iwanaga(Daido University)Masao Miyagawa(Ehime University Hospital)Toshimitsu Kameya(Sapporo Science Center)Kunihiro Nakada(Sapporo Science Center)Yuko Kawai(Sapporo Science Center)Masayuki Tsujisaki(Sapporo Science Center)
Abstract
Our findings, being against the conventional view, indicate the high incidence of metabolically active BAT in adult humans and suggest a role in the control of body temperature and adiposity.
Adipose Tissue and MetabolismDiet and metabolism studiesMuscle metabolism and nutritionBrown adipose tissueAdipose tissueMedicineIncidence (geometry)Internal medicineEndocrinologyPositron emission tomographyPhysiologyNuclear medicine
MeSH terms
Adipose TissueAdultAutopsyAdipose Tissue, BrownCold TemperatureEnvironmental ExposureFemaleHumansMaleReference ValuesSeasonsTomography, X-Ray ComputedAdipocytesFluorodeoxyglucose F18Positron-Emission Tomography
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Ministerio de Educación, Cultura y Deporte
- Japan Society for the Promotion of Science
Citations
1,824
FWCI
43.02
field-weighted impact
References
30
Percentile
100%
vs. same field & year
Citations per year
Cited by
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
American Journal of Physiology-Endocrinology and Metabolism · 2010 · 749 citations
Central circuitries for body temperature regulation and fever
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2011 · 528 citations
Brown and beige fat: development, function and therapeutic potential
Nature Medicine · 2013 · 2,280 citations
Brown and Beige Fat: Physiological Roles beyond Heat Generation
Cell Metabolism · 2015 · 991 citations
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cell Metabolism · 2015 · 994 citations
References
Unexpected evidence for active brown adipose tissue in adult humans
American Journal of Physiology-Endocrinology and Metabolism · 2007 · 1,783 citations
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
Cell Metabolism · 2009 · 1,299 citations
Brown Adipose Tissue: Function and Physiological Significance
Physiological Reviews · 2004 · 6,318 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.