review Open AccessTop 1% cited

Brown and Beige Fat: Physiological Roles beyond Heat Generation

Cell Metabolism · 2015 · Vol. 22(4) · pp. 546–559

Shingo Kajimura✉(University of California, San Francisco)Bruce M. Spiegelman(Dana-Farber Cancer Institute)Patrick Seale(University of Pennsylvania)

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Adipose Tissue and Metabolism Exercise and Physiological Responses Lipid metabolism and biosynthesisBiologyCell biology

MeSH terms

Uncoupling Protein 1AnimalsAdipose Tissue, BrownEnergy MetabolismHumansImmunity, InnateIon ChannelsMetabolic DiseasesObesityCell LineageRNA, UntranslatedMitochondrial Proteins

Funding

JPB Foundation
National Institutes of Health
Japan Science and Technology Agency

Citations

991

FWCI

42.04

field-weighted impact

References

164

Percentile

100%

vs. same field & year

Citations per year

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References

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Journal of Clinical Investigation · 1994 · 3,471 citations

Transcriptional Control of Brown Fat Determination by PRDM16

Cell Metabolism · 2007 · 1,155 citations

Unexpected evidence for active brown adipose tissue in adult humans

American Journal of Physiology-Endocrinology and Metabolism · 2007 · 1,783 citations

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

American Journal of Physiology-Endocrinology and Metabolism · 2010 · 749 citations

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Cell Metabolism · 2009 · 1,299 citations

Brown and beige fat: development, function and therapeutic potential

Nature Medicine · 2013 · 2,280 citations

Brown Adipose Tissue: Function and Physiological Significance

Physiological Reviews · 2004 · 6,318 citations

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

American Journal of Physiology-Cell Physiology · 2000 · 580 citations

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