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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

Acta Neuropathologica · 2011 · Vol. 121(3) · pp. 397–405

Genevieve Schindler✉(University Hospital Heidelberg)David Capper(Heidelberg University)Jochen Meyer(Heidelberg University)Wibke G. Janzarik(University Medical Center Freiburg)Heymut Omran(University Medical Center Freiburg)Christel Herold‐Mende(Heidelberg University)Kirsten Schmieder(University Hospital Heidelberg)Pieter Wesseling(Radboud University Medical Center)Christian Mawrin(Otto-von-Guericke University Magdeburg)Martin Hasselblatt(University Hospital Münster)David N. Louis(Massachusetts General Hospital)Andrey Korshunov(Heidelberg University)Stefan M. Pfister(German Cancer Research Center)Christian Hartmann(Heidelberg University)Werner Paulus(University Hospital Münster)Guido Reifenberger(Heinrich Heine University Düsseldorf)Andreas von Deimling(Heidelberg University)

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Glioma Diagnosis and Treatment Ocular Oncology and Treatments Neurofibromatosis and Schwannoma CasesGangliogliomaPilocytic astrocytomaPleomorphic xanthoastrocytomaPathologyBiologyMissense mutationV600ECancer researchNonsense mutationGlioma

MeSH terms

AdolescentAdultAstrocytomaBrain NeoplasmsChildChild, PreschoolExonsGene FrequencyHumansNervous System NeoplasmsRetrospective StudiesWorld Health OrganizationSignal TransductionGangliogliomaMutation, Missense

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