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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
Diabetes · 2008 · Vol. 57(12) · pp. 3239–3246
Carey N. Lumeng✉(University of Michigan–Ann Arbor)Jennifer B. DelProposto(University of Michigan–Ann Arbor)Daniel J. Westcott(University of Michigan–Ann Arbor)Alan R. Saltiel(University of Michigan–Ann Arbor)
Abstract
The shift in the M2a/M1 ATM balance is generated by spatial and temporal differences in the recruitment of distinct ATM subtypes. The obesity-induced switch in ATM activation state is coupled to the localized recruitment of an inflammatory ATM subtype to macrophage clusters from the circulation and not to the conversion of resident M2a macrophages to M1 ATMs in situ.
Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancerAdipose Tissue and MetabolismAdipose tissueMacrophagePopulationAdipose tissue macrophagesAdipogenesisChemistryPhenotypeCCL2CCR2Internal medicine
MeSH terms
Adipose TissueAnimalsAsialoglycoproteinsDietFlow CytometryMacrophage ActivationMacrophagesMembrane ProteinsMice, Inbred C57BLObesityPhenotypeGene ExpressionMice, KnockoutLectins, C-TypeMice
Funding
- National Institutes of Health
Citations
891
FWCI
22.26
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
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References
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Diabetes · 2007 · 973 citations
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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Journal of Clinical Investigation · 2007 · 4,525 citations
Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity
Diabetes · 2006 · 1,004 citations
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