article Open AccessTop 1% cited
Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression
American Journal Of Pathology · 2005 · Vol. 166(2) · pp. 409–419
Fengjun Wang(Southwest Hospital)W. Vallen Graham(University of Chicago)Yingmin Wang(University of Chicago)Edwina D. Witkowski(University of Chicago)Brad T. Schwarz(University of Chicago)Jerrold R. Turner✉(University of Chicago)
Helicobacter pylori-related gastroenterology studiesBarrier Structure and Function StudiesInflammatory Bowel DiseaseMyosin light-chain kinaseTumor necrosis factor alphaMyosinBiologyNecrosisCancer researchInterferonKinaseCell biologyImmunology
MeSH terms
Dose-Response Relationship, DrugElectrophoresis, Polyacrylamide GelHumansInterferon-gammaMicroscopy, FluorescenceMyosin-Light-Chain KinasePhosphorylationSulfasalazineTime FactorsTumor Necrosis Factor-alphaImmunoblottingUp-RegulationCytokinesNF-kappa BCaco-2 Cells
Funding
- University of Chicago
- National Institutes of Health
Citations
675
FWCI
19.72
field-weighted impact
References
58
Percentile
100%
vs. same field & year
Citations per year
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References
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
American Journal of Physiology-Cell Physiology · 1997 · 540 citations
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: a new action for an old drug
Leukemia · 2001 · 629 citations
TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2004 · 871 citations
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