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Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Cell stem cell · 2013 · Vol. 12(4) · pp. 487–496

Takayuki Kondo(Kyoto University)Masashi Asai(Japan Science and Technology Agency)Kayoko Tsukita(Kyoto University)Yumiko Kutoku(Kawasaki Medical School)Yutaka Ohsawa(Kawasaki Medical School)Yoshihide Sunada(Kawasaki Medical School)Keiko Imamura(Kyoto University)Naohiro Egawa(Kyoto University)Naoki Yahata(Kyoto University)Keisuke Okita(Kyoto University)Kazutoshi Takahashi(Kyoto University)Isao Asaka(Kyoto University)Takashi Aoi(Kyoto University)Akira Watanabe(Kyoto University)Kaori Watanabe(Japan Science and Technology Agency)Chie Kadoya(Japan Science and Technology Agency)Rie Nakano(Japan Science and Technology Agency)Dai Watanabe(Kyoto University)Kei Maruyama(Saitama Medical University)Osamu Hori(Kanazawa University)Satoshi Hibino(Fukuyama University)Tominari Choshi(Fukuyama University)Tatsutoshi Nakahata(Kyoto University)Hiroyuki Hioki(Kyoto University)Takeshi Kaneko(Kyoto University)Motoko Naitoh(Kyoto University)Katsuhiro Yoshikawa(Kyoto University)Satoko Yamawaki(Kyoto University)Shigehiko Suzuki(Kyoto University)Ryuji Hata(Ehime University)Shu-ichi Ueno(Ehime University)Tsuneyoshi Seki(Kobe University)Kazuhiro Kobayashi(Kobe University)Tatsushi Toda(Kobe University)Kazuma Murakami(Kyoto University)Kazuhiro Irie(Kyoto University)William L. Klein(Northwestern University)Hiroshi Mori(Osaka City University)Takashi Asada(University of Tsukuba)Ryōsuke Takahashi(Kyoto University)Nobuhisa Iwata✉(Japan Science and Technology Agency)Shinya Yamanaka(Kyoto University)Haruhisa Inoue✉(Kyoto University)

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Alzheimer's disease research and treatments Computational Drug Discovery Methods Cholinesterase and Neurodegenerative DiseasesBiologyPhenotypeDiseaseIntracellularDrugInduced pluripotent stem cellDrug discoveryNeuroscienceCell biologyBioinformatics

MeSH terms

Alzheimer DiseaseCell DifferentiationCerebral CortexDocosahexaenoic AcidsHumansModels, BiologicalNeuronsPhenotypeAmyloid beta-PeptidesOxidative StressProtein Structure, QuaternaryIntracellular SpaceMutant ProteinsInduced Pluripotent Stem Cells

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Alzheimer’s disease: experimental models and reality