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Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
New England Journal of Medicine · 2008 · Vol. 359(21) · pp. 2195–2207
Paul M. Ridker✉(Brigham and Women's Hospital)Eleanor Danielson(Brigham and Women's Hospital)Francisco Antônio Helfenstein Fonseca(Universidade Federal de São Paulo)Jacques Genest(McGill University Health Centre)Antonio M. GottoJohn J.P. Kastelein(University of Amsterdam)Wolfgang Köenig(Universität Ulm)Peter Libby(Harvard University)Alberto Lorenzatti(Servicio Diabetología Hospital Córdoba)Jean MacFadyen(Harvard University)Børge G. Nordestgaard(Herlev Hospital)James Shepherd(University of Glasgow)James T. Willerson(St. Luke's Episcopal Hospital)Robert J. Glynn(Harvard University)
Abstract
In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. (ClinicalTrials.gov number, NCT00239681.)
Lipoproteins and Cardiovascular HealthAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsRosuvastatinMedicineHazard ratioC-reactive proteinRosuvastatin CalciumInternal medicineMyocardial infarctionConfidence intervalStatinPlacebo
MeSH terms
Rosuvastatin CalciumAgedC-Reactive ProteinCardiovascular DiseasesDiabetes MellitusDouble-Blind MethodFemaleFluorobenzenesFollow-Up StudiesGlycated HemoglobinHumansCholesterol, LDLMaleMiddle AgedMuscular Diseases
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