articleTop 1% cited
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels
JAMA · 1998 · Vol. 279(20) · pp. 1615–1615
John R. Downs✉(Kirtland Air Force Base)Michael Clearfield(University of North Texas)Stephen E. Weis(University of North Texas)Edwin J. WhitneyDeborah R. Shapiro(Merck (Japan))Polly A. Beere(Merck (Japan))Alexandra Langendörfer(Merck (Japan))Evan A. SteinWilliam B. KruyerAntonio M. Gotto(Cornell University)
Abstract
Lovastatin reduces the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL-C levels. These findings support the inclusion of HDL-C in risk-factor assessment, confirm the benefit of LDL-C reduction to a target goal, and suggest the need for reassessment of the National Cholesterol Education Program guidelines regarding pharmacological intervention.
Lipoproteins and Cardiovascular HealthAntiplatelet Therapy and Cardiovascular DiseasesAtherosclerosis and Cardiovascular DiseasesMedicineLovastatinInternal medicinePlaceboCholesterolPercentileTriglycerideNational Health and Nutrition Examination SurveyCoronary artery diseaseCohort
MeSH terms
AgedAnticholesteremic AgentsCoronary DiseaseDouble-Blind MethodFemaleFollow-Up StudiesHumansCholesterol, HDLCholesterol, LDLLovastatinMaleMiddle AgedReference ValuesRisk FactorsTriglycerides
Funding
- University of North Texas
Citations
5,284
FWCI
337.56
field-weighted impact
References
20
Percentile
100%
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Citations per year
Cited by
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References
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Clinical Chemistry · 1972 · 32,293 citations
Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
JAMA · 1993 · 27,890 citations
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
New England Journal of Medicine · 1995 · 7,469 citations
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
The Lancet · 1994 · 8,489 citations
The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
New England Journal of Medicine · 1996 · 7,478 citations
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