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Predominant Hematopoietic Origin of Cell-free DNA in Plasma and Serum after Sex-mismatched Bone Marrow Transplantation
Clinical Chemistry · 2002 · Vol. 48(3) · pp. 421–427
Yanni YN Lui(Chinese University of Hong Kong)Ki-Wai Chik(Chinese University of Hong Kong)Rossa W. K. Chiu(Chinese University of Hong Kong)Cheong-Yip Ho(Prince of Wales Hospital)Christopher WK Lam(Prince of Wales Hospital)YM Dennis Lo✉(Chinese University of Hong Kong)
Abstract
After bone marrow transplantation, the DNA in plasma and serum is predominantly hematopoietic in origin. Apart from the biological implications of this observation, this finding suggests that plasma and serum can be used as alternative materials for the study of postbone marrow transplantation chimerism.
Prenatal Screening and DiagnosticsCancer Genomics and DiagnosticsRenal and related cancersBuffy coatBone marrowTransplantationDNAHaematopoiesisAndrologyBiologyHematopoietic stem cell transplantationMolecular biologyMedicine
MeSH terms
Cell CompartmentationDNAFemaleHematopoiesisHumansMalePlasmaSex FactorsBone Marrow TransplantationTransplantation Chimera
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References
Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis
The American Journal of Human Genetics · 1998 · 1,649 citations
Real time quantitative PCR.
Genome Research · 1996 · 6,197 citations
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