articleTop 10% cited

Cystatin C: An Improved Estimator of Glomerular Filtration Rate?

Clinical Chemistry · 2002 · Vol. 48(5) · pp. 699–707

Omar Laterza(Washington University in St. Louis)Christopher P. Price(Royal London Hospital)Mitchell G. Scott✉(Washington University in St. Louis)

View via DOI Publisher page

Abstract

Studies of reference intervals for CysC overwhelmingly demonstrated that CysC values in blood are independent of age and sex. Of the 24 studies that examined clinical utility, 15 concluded that CysC is superior to SCr, whereas 9 concluded that CysC is equivalent but provides no advantage. Summary ROC plot analysis of 20 studies that provide sensitivity and specificity data strongly suggests that CysC will be superior to SCr for detecting impaired GFR. Taken together, it is clear that CysC performs at least as well as SCr in the population at large and that it is likely to be superior to SCr in specific patient populations.

Chronic Kidney Disease and Diabetes Dialysis and Renal Disease Management Renal and Vascular PathologiesCystatin CRenal functionMedicineCreatinineUrologyInternal medicinePopulationCystatinNarrative reviewIntensive care medicine

MeSH terms

Blood Urea NitrogenCreatinineGlomerular Filtration RateHumansKidney DiseasesReference ValuesROC CurveBiomarkersCystatinsKidney TransplantationCystatin CDrug-Related Side Effects and Adverse Reactions

Citations

658

FWCI

9.88

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program