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Mortality in systemic lupus erythematosus

Arthritis & Rheumatism · 2006 · Vol. 54(8) · pp. 2550–2557

Sasha Bernatsky✉(Montreal General Hospital)J.‐F. Boivin(McGill University)L. Joseph(Montreal General Hospital)S Manzi(University of Pittsburgh)Ellen M. Ginzler(SUNY Downstate Health Sciences University)Dafna D. Gladman(Toronto Western Hospital)Murray B. Urowitz(Toronto Western Hospital)Paul R. Fortin(Toronto Western Hospital)Michelle Petri(Johns Hopkins University)Susan G. Barr(University of Calgary)Caroline Gordon(University of Birmingham)Sang‐Cheol Bae(Hanyang University Seoul Hospital)David Isenberg(UCL Australia)Asad Zoma(NHS Lanarkshire)Cynthia Aranow(Yeshiva University)Mary Anne Dooley(University of North Carolina at Chapel Hill)Ola Nived(Lund University)Gunnar Sturfelt(Lund University)K Steinsson(National University Hospital of Iceland)Graciela S. Alarcón(University of Alabama at Birmingham)Jean‐Luc Senécal(Université de Montréal)Michel Zummer(Hôpital Maisonneuve-Rosemont)JG Hanly(Dalhousie University)Stephanie Ensworth(University of British Columbia)Janet Pope(Western University)Steven M. Edworthy(University of Calgary)Anisur Rahman(UCL Australia)John Sibley(Royal University Hospital)Hani El‐Gabalawy(University of Manitoba)T McCarthy(University of Manitoba)Y. St. Pierre(McGill University)Ann E. Clarke(McGill University)Rosalind Ramsey‐Goldman(Northwestern University)

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Abstract

Our data from a very large multicenter international cohort emphasize what has been demonstrated previously in smaller samples. These results highlight the increased mortality rate in SLE patients compared with the general population, and they suggest particular risk associated with female sex, younger age, shorter SLE duration, and black/African American race. The risk for certain types of deaths, primarily related to lupus activity (such as renal disease), has decreased over time, while the risk for deaths due to circulatory disease does not appear to have diminished.

Systemic Lupus Erythematosus Research Atherosclerosis and Cardiovascular Diseases Systemic Sclerosis and Related DiseasesMedicineStandardized mortality ratioCohortMortality ratePopulationConfidence intervalSystemic lupus erythematosusCohort studyInternal medicineEpidemiology

MeSH terms

AdolescentAdultCause of DeathFemaleUnited KingdomHumansIcelandInternational CooperationKoreaLupus Erythematosus, SystemicMaleMiddle AgedNorth AmericaRegistriesSweden