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The frequency and outcome of lupus nephritis: results from an international inception cohort study

Lara D. Veeken · 2015 · Vol. 55(2) · pp. 252–262

John G. Hanly✉(Queen Elizabeth II Health Sciences Centre)Aidan G. O’Keeffe(University College London)Li Su(MRC Biostatistics Unit)Murray B. Urowitz(University of Toronto)Juanita Romero‐Díaz(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)Caroline Gordon(University of Birmingham)Sang‐Cheol Bae(Hanyang University Seoul Hospital)Sasha Bernatsky(McGill University Health Centre)Ann E. Clarke(University of Calgary)Daniel J. Wallace(Cedars-Sinai Medical Center)Joan T. Merrill(Oklahoma Medical Research Foundation)David Isenberg(University College London)Anisur Rahman(University College London)Ellen M. Ginzler(SUNY Downstate Health Sciences University)Paul R. Fortin(Université Laval)Dafna D. Gladman(University of Toronto)Jorge Sánchez‐Guerrero(Toronto Western Hospital)Michelle Petri(Johns Hopkins University)Ian N Bruce(Manchester Academic Health Science Centre)Mary Anne Dooley(University of North Carolina at Chapel Hill)Rosalind Ramsey‐Goldman(Northwestern University)Cynthia Aranow(Feinstein Institute for Medical Research)Graciela S. Alarcón(University of Alabama at Birmingham)Barri J. Fessler(University of Alabama at Birmingham)Kristján Steinsson(National University Hospital of Iceland)Ola Nived(Lund University)Gunnar Sturfelt(Lund University)Susan Manzi(University of Pittsburgh)Munther A. Khamashta(King's College London)Ronald van Vollenhoven(Karolinska Institutet)Asad Zoma(Hairmyres Hospital)Manuel Ramos‐Casals(Consorci Institut D'Investigacions Biomediques August Pi I Sunyer)Guillermo Ruiz‐Irastorza(BioCruces Health research Institute)S. Sam Lim(Emory University)Thomas Stoll(Spitäler Schaffhausen)Murat İnanç(Istanbul University)Kenneth Kalunian(University of California San Diego)Diane L. Kamen(Medical University of South Carolina)Peter J. Maddison(Ysbyty Gwynedd Hospital NHS Trust)Christine Peschken(University of Manitoba)Søren Jacobsen(Rigshospitalet)Anca Askanase(New York University Langone Orthopedic Hospital)Chris Theriault(Queen Elizabeth II Health Sciences Centre)Kara Thompson(Dalhousie University)Vernon T. Farewell(MRC Biostatistics Unit)

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Abstract

LN occurred in 38.3% of SLE patients, frequently as the initial presentation, in a large multi-ethnic inception cohort. Despite current standard of care, nephritis was associated with ESRD and death, and renal insufficiency was linked to lower health-related quality of life. Further advances are required for the optimal treatment of LN.

Systemic Lupus Erythematosus Research Atherosclerosis and Cardiovascular Diseases Renal Diseases and GlomerulopathiesMedicineLupus nephritisInternal medicineCohortProteinuriaRenal functionIncidence (geometry)Prospective cohort studyQuality of life (healthcare)Cohort study

MeSH terms

AdultEthnicityFemaleFollow-Up StudiesHumansLupus NephritisMaleProspective StudiesQuality of LifeSurveys and QuestionnairesRisk FactorsGlobal HealthIncidenceSurvival RateOutcome Assessment, Health Care