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H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

Neuropsychopharmacology · 2003 · Vol. 28(3) · pp. 519–526
Wesley K. KroezeSandra J. HufeisenBeth A PopadakSean M RenockS SteinbergPaul ErnsbergerKaru JayathilakeHerbert Y. MeltzerBryan L. Roth
Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityReceptorHistamine H1 receptorAtypical antipsychoticAntipsychoticPharmacology5-HT1 receptorHistamine receptorNeurotransmitter receptor5-HT receptorDopamine receptor D2

MeSH terms

AnimalsDrug Evaluation, PreclinicalForecastingHumansProtein BindingReceptors, Histamine H1Antipsychotic AgentsWeight GainDiscriminant AnalysisStatistics, Nonparametric

Funding

  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health
Citations
789
FWCI
9.57
field-weighted impact
References
51
Percentile
99%
vs. same field & year
Citations per year
References
The Role of Serotonin in Antipsychotic Drug Action
Neuropsychopharmacology · 1999 · 666 citations
Atypical antipsychotics and weightgain — a systematic review
Acta Psychiatrica Scandinavica · 2000 · 407 citations
Clozapine for the Treatment-Resistant Schizophrenic
Archives of General Psychiatry · 1988 · 4,110 citations
Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.
Journal of Pharmacology and Experimental Therapeutics · 1989 · 1,350 citations
Antipsychotic-Induced Weight Gain: A Comprehensive Research Synthesis
American Journal of Psychiatry · 1999 · 2,384 citations
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