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Antipsychotic-Induced Weight Gain: A Comprehensive Research Synthesis

American Journal of Psychiatry · 1999 · Vol. 156(11) · pp. 1686–1696

David B. Allison✉(St. Luke's-Roosevelt Hospital Center)Janet L. MentoreMoonseong HeoL.P. ChandlerJoseph C. CappelleriMing C. InfantePeter J. Weiden

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Abstract

Both conventional and newer antipsychotics are associated with weight gain. Among the newer agents, clozapine appears to have the greatest potential to induce weight gain, and ziprasidone the least. The differences among newer agents may affect compliance with medication and health risk.

Schizophrenia research and treatment Diet and metabolism studies Treatment of Major DepressionWeight gainPlaceboAntipsychoticBody weightPsychologyWeight lossMedicineAnimal sciencePsychotherapistInternal medicine

MeSH terms

Clinical Trials as TopicClozapineDrug Administration ScheduleHumansMolindonePiperazinesPlacebosPsychotic DisordersResearch DesignThiazolesAntipsychotic AgentsWeight GainConfidence IntervalsTreatment Outcome

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2,384

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42.10

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Cited by

Overweight and Obesity: Prevalence, Consequences, and Causes of a Growing Public Health Problem