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Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

Journal of Nutrition · 2000 · Vol. 130(10) · pp. 2413–2419
Joshua C. AnthonyFumiaki YoshizawaTracy G. AnthonyThomas C. VaryLeonard S. JeffersonScot R. Kimball✉
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Muscle metabolism and nutritionPI3K/AKT/mTOR signaling in cancerMuscle Physiology and DisordersLeucineP70-S6 Kinase 1EIF4ERibosomal protein s6Eukaryotic initiation factorPhosphorylationSkeletal muscleProtein biosynthesisPI3K/AKT/mTOR pathwayBiology

MeSH terms

AnimalsCarrier ProteinsElectrophoresis, Polyacrylamide GelFoodFood DeprivationIsoleucineLeucineMaleMuscle ProteinsPeptide Initiation FactorsPhosphoproteinsPhosphorylationProtein BiosynthesisValineRats, Sprague-Dawley
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References
A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine
Biochemical Journal · 1980 · 976 citations
Initiation of Protein Synthesis in Eukaryotic Cells
European Journal of Biochemistry · 1996 · 712 citations
Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation
Molecular and Cellular Biology · 1994 · 1,012 citations
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Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway
Journal of Nutrition · 2000 · 792 citations
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