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Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
American Journal Of Pathology · 2007 · Vol. 172(1) · pp. 146–155
John S. Tzartos(University of Oxford)Manuel A. Friese(John Radcliffe Hospital)Matthew Craner(United BioSource Corporation (United Kingdom))Jackie Palace(University of Oxford)Jia Newcombe(Aarhus University Hospital)Margaret M. Esiri✉(John Radcliffe Hospital)Lars Fugger(University of Oxford)
Psoriasis: Treatment and PathogenesisMultiple Sclerosis Research StudiesCytokine Signaling Pathways and InteractionsCentral nervous systemMultiple sclerosisDiseasePathologyNeurogliaMedicineCentral nervous system diseaseBiologyImmunologyNeuroscience
MeSH terms
AdultAgedBrainCell DifferentiationCentral Nervous SystemHumansLymph NodesMiddle AgedMultiple SclerosisNeurogliaT-LymphocytesCD4-Positive T-LymphocytesCase-Control StudiesCD8-Positive T-LymphocytesInterleukin-17
Funding
- Scleroseforeningen
- University College London
- European Commission
- Deutsche Forschungsgemeinschaft
- Lundbeckfonden
- H. Lundbeck A/S
Citations
1,168
FWCI
20.84
field-weighted impact
References
50
Percentile
100%
vs. same field & year
Citations per year
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References
IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis
The Journal of Immunology · 2006 · 1,525 citations
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
The Journal of Experimental Medicine · 2005 · 4,029 citations
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Nature Immunology · 2007 · 1,798 citations
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
Nature Immunology · 2007 · 1,424 citations
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Journal of Clinical Investigation · 1999 · 1,678 citations
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
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IMMUNOLOGY OF MULTIPLE SCLEROSIS
Annual Review of Immunology · 2005 · 2,143 citations
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Nature Immunology · 2007 · 1,799 citations
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