articleTop 10% cited
SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7
Molecular Pharmacology · 2004 · Vol. 65(3) · pp. 744–752
Stacey DaCosta Byfield✉(National Institutes of Health)Christopher MajorNicholas J. LapingAnita B. Roberts
TGF-β signaling in diseasesConnective Tissue Growth Factor ResearchBone Metabolism and DiseasesSMADSignal transductionKinaseTGF beta receptor 2ReceptorTransforming growth factorProtein kinase ACell biologyChemistryTransforming growth factor beta
MeSH terms
Receptor, Transforming Growth Factor-beta Type IAnimalsBenzamidesDioxolesDNA-Binding ProteinsDrug InteractionsHumansProteinsTumor Cells, CulturedTrans-ActivatorsTransforming Growth Factor betaCell DeathProtein Serine-Threonine KinasesGenes, ReporterReceptors, Transforming Growth Factor beta
Citations
414
FWCI
7.21
field-weighted impact
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38
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98%
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References
TGF-β signaling in tumor suppression and cancer progression
Nature Genetics · 2001 · 2,272 citations
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
The EMBO Journal · 2002 · 1,119 citations
TGF-β SIGNAL TRANSDUCTION
Annual Review of Biochemistry · 1998 · 7,560 citations
Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542
Molecular Pharmacology · 2002 · 647 citations
SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
Molecular Pharmacology · 2002 · 1,647 citations
TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?
International Journal of Radiation Oncology*Biology*Physics · 2000 · 642 citations
Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene
The EMBO Journal · 1998 · 1,788 citations
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