article Open AccessTop 1% cited
Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
Cancer Cell · 2011 · Vol. 20(1) · pp. 11–24
Kelly Moran-Crusio(New York University)Linsey B. Reavie(New York University)Alan H. Shih(Memorial Sloan Kettering Cancer Center)Omar Abdel‐Wahab(Memorial Sloan Kettering Cancer Center)Delphine Ndiaye‐Lobry(New York University)Camille Lobry(New York University)María E. Figueroa(Cornell University)Aparna Vasanthakumar(University of Chicago)Jay Patel(Memorial Sloan Kettering Cancer Center)Xinyang Zhao(Kettering University)Fabiana Perna(Kettering University)Suveg Pandey(Memorial Sloan Kettering Cancer Center)Jozef Madžo(University of Chicago)Chun‐Xiao Song(University of Chicago)Qing Dai(University of Chicago)Chuan He(University of Chicago)Sherif Ibrahim(New York University)Miloslav Beran(The University of Texas MD Anderson Cancer Center)Jiří Zavadil(NYU Langone Health)Stephen D. Nimer(Memorial Sloan Kettering Cancer Center)Ari Melnick(Cornell University)Lucy A. Godley(University of Chicago)Iannis Aifantis✉(Howard Hughes Medical Institute)Ross L. Levine✉(Memorial Sloan Kettering Cancer Center)
Acute Myeloid Leukemia ResearchEpigenetics and DNA MethylationImmune cells in cancerHaematopoiesisTransformation (genetics)MyeloidStem cellHematopoietic stem cellCell biologyMyeloid cellsBiologyCancer researchGenetics
MeSH terms
AllelesAnimalsCell Transformation, NeoplasticDNA-Binding ProteinsHematopoiesisHematopoietic Stem CellsHumansProto-Oncogene ProteinsLeukemia, Myelomonocytic, ChronicGene DeletionGene SilencingMyeloid CellsCell ProliferationDioxygenasesMice
Funding
- National Institutes of Health
Citations
1,293
FWCI
47.16
field-weighted impact
References
41
Percentile
100%
vs. same field & year
Citations per year
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References
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Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
Leukemia · 2010 · 521 citations
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Cancer Cell · 2010 · 2,713 citations
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Bioinformatics · 2003 · 8,399 citations
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Proceedings of the National Academy of Sciences · 2005 · 55,472 citations
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Cancer Cell · 2011 · 2,803 citations
Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells
Cell stem cell · 2011 · 776 citations
The roles of FLT3 in hematopoiesis and leukemia
Blood · 2002 · 1,535 citations
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