reviewTop 1% cited
Fluorine in medicinal chemistry
Chemical Society Reviews · 2007 · Vol. 37(2) · pp. 320–330
Sophie Purser(Oxford Research Group)Peter R. Moore(AstraZeneca (United Kingdom))Steve Swallow(AstraZeneca (United Kingdom))Véronique Gouverneur✉(Oxford Research Group)
Abstract
It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Fluorine in Organic ChemistrySynthesis and Biological EvaluationSynthesis and Reactions of Organic CompoundsFluorineChemistryCombinatorial chemistryOrganic chemistry
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