articleTop 10% cited

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Journal of Pharmaceutical Sciences · 2006 · Vol. 95(6) · pp. 1238–1257

Trudy Rodgers✉(University of Manchester)Malcolm Rowland(University of Manchester)

Drug Transport and Resistance Mechanisms Pharmacogenetics and Drug Metabolism Analytical Chemistry and ChromatographyPharmacokineticsChemistryAdipose tissuePartition coefficientDistribution (mathematics)Component (thermodynamics)ChromatographyPharmacologyBiochemistryThermodynamics

MeSH terms

OctanolsAnimalsBlood ProteinsBody Fluid CompartmentsComputer SimulationErythrocytesModels, BiologicalPharmacokineticsPhospholipidsPredictive Value of TestsTissue DistributionWaterQuantitative Structure-Activity RelationshipRats

Citations

931

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7.21

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Cited by

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

Clinical Pharmacology & Therapeutics · 2010 · 511 citations

References

Physiological Parameters in Laboratory Animals and Humans

Pharmaceutical Research · 1993 · 2,894 citations

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Journal of Pharmaceutical Sciences · 2002 · 558 citations

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Journal of Pharmaceutical Sciences · 2005 · 771 citations

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