articleTop 10% cited

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Journal of Pharmaceutical Sciences · 2002 · Vol. 91(1) · pp. 129–156

Patrick Poulin✉(Roche (Switzerland))Frank‐Peter Theil(Roche (Switzerland))

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Computational Drug Discovery MethodsIn vivoLipophilicityVolume of distributionPharmacokineticsChemistryDistribution (mathematics)Distribution VolumeVolume (thermodynamics)Partition coefficientPharmacology

MeSH terms

AnimalsChemistry, PhysicalPharmaceutical PreparationsHumansModels, BiologicalModels, ChemicalPharmacokineticsTissue DistributionRatsChemical Phenomena

Citations

558

FWCI

13.01

field-weighted impact

References

235

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99%

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