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Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
New England Journal of Medicine · 2014 · Vol. 371(11) · pp. 993–1004
John J.V. McMurray✉Milton Packer(The University of Texas Southwestern Medical Center)Akshay S. Desai(Brigham and Women's Hospital)Jianjian GongMartin LefkowitzAdel R. RizkalaJean L. Rouleau(Montreal Heart Institute)Victor ShiScott D. Solomon(Brigham and Women's Hospital)Karl Swedberg(Imperial College London)Michael R. Zile(Ralph H. Johnson VA Medical Center)
Abstract
LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure. (Funded by Novartis; PARADIGM-HF ClinicalTrials.gov number, NCT01035255.).
Heart Failure Treatment and ManagementElectrolyte and hormonal disordersCardiovascular Function and Risk FactorsEnalaprilNeprilysinHeart failureInternal medicineCardiologyRenin–angiotensin systemMedicineAngiotensin-converting enzymeChemistryBlood pressure
MeSH terms
ValsartanAgedAminobutyratesAngiotensin-Converting Enzyme InhibitorsBiphenyl CompoundsDouble-Blind MethodDrug CombinationsEnalaprilFemaleHeart FailureHospitalizationHumansMaleMiddle AgedStroke Volume
Citations
6,700
FWCI
242.37
field-weighted impact
References
30
Percentile
100%
vs. same field & year
Citations per year
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References
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)
The Lancet · 1999 · 5,094 citations
Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure
Journal of the American College of Cardiology · 2000 · 1,771 citations
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The Lancet · 1999 · 4,886 citations
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
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Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure
New England Journal of Medicine · 1991 · 8,029 citations
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