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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
New England Journal of Medicine · 1999 · Vol. 341(10) · pp. 709–717
Bertram Pitt✉(University of Michigan–Ann Arbor)Faı̈ez Zannad(Centre d’Investigation Clinique Innovation Technologique de Nancy)Willem J. RemmeRobert Cody(University of Michigan–Ann Arbor)A CastaigneA.J. Pérez PérezJolie Palensky(Statistics Collaborative)Janet Wittes(Statistics Collaborative)
Abstract
Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
Hormonal Regulation and HypertensionHeart Failure Treatment and ManagementBlood Pressure and Hypertension StudiesSpironolactoneMedicineHeart failureDigoxinInternal medicineRelative riskPlaceboEjection fractionCardiologyConfidence interval
MeSH terms
AgedMineralocorticoid Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCause of DeathDiureticsDouble-Blind MethodDrug Therapy, CombinationFemaleGynecomastiaHeart DiseasesHeart FailureHospitalizationHumansHyperkalemiaMale
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