articleTop 10% cited
Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
Journal of Pharmacology and Experimental Therapeutics · 2002 · Vol. 303(3) · pp. 1029–1037
Kelly M. Mahar Doan✉Joan E. Humphreys(GlaxoSmithKline (United States))Lindsey O. Webster(Research Triangle Park Foundation)Stephen A. Wring(GlaxoSmithKline (United States))Larry J. Shampine(Research Triangle Park Foundation)Cosette J. Serabjit‐Singh(Research Triangle Park Foundation)Kimberly K. Adkison(GlaxoSmithKline (United States))Joseph W. Polli(Research Triangle Park Foundation)
Drug Transport and Resistance MechanismsProtein Interaction Studies and Fluorescence AnalysisEpilepsy research and treatmentEffluxP-glycoproteinLipophilicityCentral nervous systemBlood–brain barrierPharmacologyCalceinChemistryPolar surface areaDrug
MeSH terms
AnimalsBlood-Brain BarrierCell LineCell Membrane PermeabilityCentral Nervous System AgentsDogsPharmaceutical PreparationsPermeabilityDrug Delivery SystemsATP Binding Cassette Transporter, Subfamily B, Member 1
Citations
623
FWCI
6.22
field-weighted impact
References
27
Percentile
97%
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References
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
Journal of Pharmaceutical Sciences · 1999 · 611 citations
Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery
Journal of Pharmacology and Experimental Therapeutics · 2001 · 659 citations
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