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Antibody-Mediated Rejection Criteria - an Addition to the Banff ’97 Classification of Renal Allograft Rejection

American Journal of Transplantation · 2003 · Vol. 3(6) · pp. 708–714

Lorraine C. Racusen✉(Johns Hopkins Medicine)Robert B. Colvin(Massachusetts General Hospital)Kim Solez(University of Alberta)Michael J. Mihatsch(University of Basel)Philip F. Halloran(University of Alberta)Patricia Campbell(University of Alberta)Michael Cecka(University of California, Los Angeles)Jean‐Pierre Cosyns(UCLouvain)Anthony J. Demetris(Pittsburg State University)Michael C. Fishbein(University of California, Los Angeles)Agnes B. Fogo(Vanderbilt University)Peter Furness(University of Leicester)Ian W. Gibson(Health Sciences Centre)Denis Glotz(Hôpital Européen Georges-Pompidou)P Häyry(University of Helsinki)Lawrence Hunsickern(University of Iowa)Michael Kashgarian(Yale University)Ronald H. Kerman(The University of Texas Health Science Center at Houston)Alex J. Magil(St. Paul's Hospital)Robert A. Montgomery(Johns Hopkins University)Kunio Morozumi(Nagoya City University)Volker Nickeleit(University of North Carolina at Chapel Hill)Parmjeet Randhawa(Pittsburg State University)Heinz Regele(University of Vienna)Daniel Serón(Universitat de Barcelona)Surya V. Seshan(Cornell University)Ståle Sund(Hospital IT)Kiril Trpkov(Rockyview General Hospital)

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Abstract

Antibody-mediated rejection (AbAR) is increasingly recognized in the renal allograft population, and successful therapeutic regimens have been developed to prevent and treat AbAR, enabling excellent outcomes even in patients highly sensitized to the donor prior to transplant. It has become critical to develop standardized criteria for the pathological diagnosis of AbAR. This article presents international consensus criteria for and classification of AbAR developed based on discussions held at the Sixth Banff Conference on Allograft Pathology in 2001. This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation.

Renal Transplantation Outcomes and Treatments Renal Diseases and Glomerulopathies Organ Transplantation Techniques and OutcomesMedicineTransplantationPathologicalRenal transplantPopulationIntensive care medicineKidney transplantationPathologySurgery