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PLASMAPHERESIS AND INTRAVENOUS IMMUNE GLOBULIN PROVIDES EFFECTIVE RESCUE THERAPY FOR REFRACTORY HUMORAL REJECTION AND ALLOWS KIDNEYS TO BE SUCCESSFULLY TRANSPLANTED INTO CROSS-MATCH-POSITIVE RECIPIENTS

Transplantation · 2000 · Vol. 70(6) · pp. 887–895

Robert A. Montgomery(Johns Hopkins University)Andrea A. ZacharyLorraine C. RacusenMary S. LeffellKaren E. KingJames F. BurdickWarren R. MaleyLloyd E. Ratner✉

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Abstract

In this study, we present seven patients for whom the combined therapies of PP/IVIG were successful in reversing AHR mediated by Ab specific for donor HLA antigens. Furthermore, this protocol shows promise for eliminating DSA preemptively among patients with low-titer positive antihuman globulin-enhanced, complement-dependent cytotoxicity (AHG-CDC) cross-matches, allowing the successful transplantation of these patients using a live donor without any cases of HAR.

Renal Transplantation Outcomes and Treatments Liver Disease and Transplantation Complement system in diseasesPlasmapheresisMedicineRefractory (planetary science)ImmunologyImmune systemGlobulinAntibodyBiology

MeSH terms

AdultAgedAntibodiesAntibody FormationAntibody SpecificityFemaleGraft RejectionHistocompatibility TestingHumansKidneyMaleMiddle AgedPlasmapheresisRisk FactorsKidney Transplantation

Citations

591

FWCI

12.04

field-weighted impact

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99%

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Cited by

Antibody-Mediated Rejection Criteria - an Addition to the Banff ’97 Classification of Renal Allograft Rejection