review Open AccessTop 1% cited
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Nature Reviews Genetics · 2008 · Vol. 10(1) · pp. 32–42
Michael Haberland✉Rusty L. Montgomery(The University of Texas Southwestern Medical Center)Eric N. Olson(The University of Texas Southwestern Medical Center)
Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsNuclear Receptors and SignalingBiologyHistoneGene isoformHistone deacetylaseEpigeneticsDiseaseHDAC11Computational biologyHistone deacetylase 5Gene expression
MeSH terms
AcetylationAnimalsEnzyme InhibitorsCardiomegalyHistone DeacetylasesHistonesModels, BiologicalMuscle, SkeletalGene Expression Regulation, DevelopmentalChondrocytesMiceHistone Deacetylase Inhibitors
Funding
- National Institutes of Health
Citations
2,496
FWCI
42.62
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References
123
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100%
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References
Anticancer activities of histone deacetylase inhibitors
Nature Reviews Drug Discovery · 2006 · 2,905 citations
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
Molecular Cell · 2006 · 1,476 citations
Acetylation: a regulatory modification to rival phosphorylation?
The EMBO Journal · 2000 · 1,150 citations
Histone deacetylase inhibitors: molecular mechanisms of action
Oncogene · 2007 · 1,533 citations
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