articleTop 1% cited
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
Nature Cell Biology · 2000 · Vol. 2(8) · pp. 469–475
Helen M. Beere✉(La Jolla Institute for Immunology)Beni B. Wolf(La Jolla Institute for Immunology)Kelvin Cain(MRC Toxicology Unit)Dick D. Mosser(Biotechnology Research Institute)Artin Mahboubi(La Jolla Institute for Immunology)Tomomi Kuwana(La Jolla Institute for Immunology)Pankaj Tailor(McGill University)Richard I. Morimoto(Northwestern University)Gerald M. Cohen(MRC Toxicology Unit)Douglas R. Green(La Jolla Institute for Immunology)
Heat shock proteins researchCell death mechanisms and regulationEndoplasmic Reticulum Stress and DiseaseApoptosomeCytochrome cCell biologyApoptosisCaspaseHsp70Intrinsic apoptosisProteasesBiologyHeat shock protein
MeSH terms
Binding SitesCell LineCell-Free SystemChromatography, GelCytochrome c GroupDeoxyadenine NucleotidesEnzyme ActivationEnzyme PrecursorsHot TemperatureHumansLigandsProtein BindingProtein Processing, Post-TranslationalProteinsRecombinant Proteins
Funding
- National Institutes of Health
Citations
1,498
FWCI
27.95
field-weighted impact
References
43
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100%
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References
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
Journal of Biological Chemistry · 1999 · 2,079 citations
Heat Shock Proteins Increase Resistance to Apoptosis
Experimental Cell Research · 1996 · 521 citations
Escaping Cell Death: Survival Proteins in Cancer
Experimental Cell Research · 1999 · 611 citations
Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis
Molecular and Cellular Biology · 1997 · 956 citations
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Cell · 1997 · 7,227 citations
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Cell · 1996 · 5,154 citations
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