reviewTop 1% cited
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Journal of Controlled Release · 2012 · Vol. 164(2) · pp. 192–204
Geeta Mehta✉(University of Michigan–Ann Arbor)Amy Y. Hsiao(University of Michigan–Ann Arbor)Marylou Ingram(Huntington Medical Research Institutes)Gary D. Luker(University of Michigan–Ann Arbor)Shuichi Takayama✉(Ulsan National Institute of Science and Technology)
3D Printing in Biomedical ResearchCancer Cells and MetastasisCellular Mechanics and InteractionsSpheroidDrug deliveryIn vivoIn vitroDrugMulticellular organismChemistryBiologyCell biologyPharmacology
MeSH terms
AnimalsAntineoplastic AgentsDisease Models, AnimalHumansNeoplasmsTumor Cells, CulturedDrug Delivery SystemsTreatment OutcomeSpheroids, Cellular
Citations
1,141
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171
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References
Three-dimensional cell cultures: from molecular mechanisms to clinical applications
American Journal of Physiology-Cell Physiology · 1997 · 535 citations
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
The Analyst · 2010 · 946 citations
Multicellular spheroids in ovarian cancer metastases: Biology and pathology
Gynecologic Oncology · 2009 · 416 citations
Drug penetration in solid tumours
Nature reviews. Cancer · 2006 · 2,726 citations
Spheroid-based drug screen: considerations and practical approach
Nature Protocols · 2009 · 1,670 citations
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
Biotechnology and Bioengineering · 2003 · 909 citations
Capturing complex 3D tissue physiology in vitro
Nature Reviews Molecular Cell Biology · 2006 · 2,266 citations
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